• Michele Curatolo and Lars Arendt-Nielsen.
• Department of Anesthesiology and Pain Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA; Center for Sensory Motor Interaction, Department of Health Science and Technology, School of Medicine, University of Aalborg, Fredrik Bajers Vej 7, Bld. D3, Aalborg 9220, Denmark. Electronic address: curatolo@uw.edu.
• Phys Med Rehabil Clin N Am. 2015 May 1; 26 (2): 175-84.

AbstractClinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity.Copyright © 2015 Elsevier Inc. All rights reserved.

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