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- G Bryan Young and Robert R Hammond.
- Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada. bryan.young@lhsc.on.ca
- Crit Care. 2004 Dec 1; 8 (6): 416-8.
AbstractICU-acquired limb and respiratory muscle weakness is a common, serious ICU syndrome, increasing in frequency with prolonged ICU stay and sepsis. A systematic approach facilitates precise localization of the problem within central or peripheral nervous system. Most cases relate to critical illness polyneuropathy or myopathy or a combination of both (critical illness neuromyopathy). Within the latter entity, the relative contribution of neuropathy versus myopathy varies considerably among affected patients. Muscle enzyme testing, electromyography-nerve conduction and muscle biopsy are valuable investigative tests. Nerve biopsy is less commonly needed, but is useful when vascultis is suspected.
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