• Transfus Apher Sci · Dec 2013

    Reducing the risk of hyperammonemia from transfusion of stored red blood cells.

    • Marsha Apushkin, Anne Das, Cherilyn Joseph, Edward Ki Yun Leung, Kiang-Teck J Yeo, Joseph M Baron, and Beverly W Baron.
    • Department of Pathology, The University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.
    • Transfus Apher Sci. 2013 Dec 1; 49 (3): 459-62.

    AbstractAmmonia concentration increases in red cell units (RBCs) during storage. We measured absolute amounts of ammonia (AA) per unit serially in stored RBCs and before and after removal of the supernatant by volume reduction (VR) or washing. Ammonia increased 6.4-fold in untreated units over 31 days. VR decreased AA 3.7-fold, whereas washing decreased it 38-fold (p<0.0001). At least for certain patients, e.g., infants receiving large volume transfusions and patients in liver failure, it may be advisable to use RBCs as fresh as possible and to limit infusion (by VR or washing) of ammonia in the supernatant.Copyright © 2013 Elsevier Ltd. All rights reserved.

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