• Antimicrob. Agents Chemother. · Oct 2010

    Efficacy of PTX3 in a rat model of invasive aspergillosis.

    • Pietro Lo Giudice, Silvia Campo, Antonio Verdoliva, Vincenzo Rivieccio, Franco Borsini, Rita De Santis, and Giovanni Salvatori.
    • R&D Department, Sigma-Tau SpA00040 Pomezia, RM, Italy.
    • Antimicrob. Agents Chemother. 2010 Oct 1; 54 (10): 4513-5.

    AbstractPentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus. PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate. PTX3 enhanced the survival rate and reduced the lung fungal burden of infected rats in both therapeutic and prophylactic modalities. Thus, we extended the protective activity of PTX3 in pulmonary aspergillosis to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.

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