• Acta Neurochir. Suppl. · Jan 2007

    In peripheral nerve regeneration environment enriched with activity stimulating factors improves functional recovery.

    • R Schmidhammer, T Hausner, R Hopf, S Zandieh, and H Redl.
    • Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Clinical and Experimental Traumatology, Research Center of the AUVA, Vienna, Austria. r.schmidhammer@gmx.de
    • Acta Neurochir. Suppl. 2007 Jan 1; 100: 161-7.

    AbstractEnriched environment stimulates brain plasticity processes after brain lesion. Less is known about the influence of enriched environment with activity stimulating factors as determinants of functional outcome after peripheral nerve repair. BDNF (brain-derived neurotrophic factor) plays a role in activity-dependent neuronal plasticity and changes in motor cortex in rats learning complex motor skills. Our study aimed to elucidate if enriched environment influences functional results after peripheral nerve repair. The results in this rat sciatic nerve transection and repair model showed that environment enriched with activity stimulating factors can improve functional results.

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