• E D Murphey, J F Fessler, G D Bottoms, H Latshaw, M Johnson, B Mueller, W Clark, and W Macias.
• Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
• Am. J. Vet. Res. 1997 Apr 1; 58 (4): 408-13.

ObjectiveTo determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock.Animals16 clinically normal pigs.ProcedureEndotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours.ResultsInfusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements.ConclusionsContinuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock.Clinical RelevanceContinuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment.

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