American journal of veterinary research
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Comparative Study
Effects of sample handling on total carbon dioxide concentrations in canine and feline serum and blood.
To determine whether underfilling blood collection tubes leads to in vitro reduction in serum measured total CO2 concentration ([TCO2]m) in canine and feline blood samples sufficient to create the impression of metabolic acidosis (pseudometabolic acidosis) or high anion gap. ⋯ Underfilling blood collection tubes results in a false decrease in serum [TCO2], which can contribute in part to descrepancies between blood gas and chemical analyses as estimates of plasma bicarbonate concentration. This, and other in vitro effects of sample handling and collection, may result in a false assessment of metabolic acidosis in dogs and cats.
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To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock. ⋯ Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment.