• Raquel Araujo Do Val-da Silva, José Eduardo Peixoto-Santos, Renata Caldo Scandiuzzi, Priscila Alves Balista, Mirian Bassi, Mogens Lesner Glass, Rodrigo Neves Romcy-Pereira, Orfa Yineth Galvis-Alonso, and João Pereira Leite.
• Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeiãro Preto 14049-900, Brazil.
• Neuroscience. 2016 Sep 22; 332: 88-100.

AbstractPreconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE). Rats underwent a short hypoxic episode (7% O2+93% N2; 30min on two consecutive days) preceding a 4-h SE (HSE group). Control groups were rats submitted to SE only (SE), rats subjected to hypoxia only (H) or normoxia-saline (C). Animals were monitored for the occurrence of SRS, and spatial memory performance was evaluated in the radial-arm maze. Hippocampal sections were analyzed for cell death and mossy fiber sprouting at 1 or 60days after SE. Compared to SE group, HSE had increased SE latency, reduced number of rats with SRS, reduced mossy fiber sprouting at 60days, and reduced cell death in the hilus and the CA3 region 1 and 60days after SE. Additionally, HSE rats had better spatial memory performance than SE rats. Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory.Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

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