• Maria Laura Canale, Andrea Camerini, Stefano Stroppa, Romana Prosperi Porta, Paolo Caravelli, Mario Mariani, Alberto Balbarini, and Sergio Ricci.
• U.O. Malattie Cardiovascolari I Universitaria, Dipartimento Cardiotoracico, Italy. marialauracanale@katamail.com
• J Cardiovasc Med (Hagerstown). 2006 Nov 1; 7 (11): 835-7.

AbstractCardiac toxicity is an uncommon side-effect of 5-fluorouracil (5-FU) treatment, consisting mainly of chest pain episodes with or without electrocardiographic changes and dysrhythmias. Here, we describe the case of a 56-year-old male patient with a diagnosis of advanced colorectal cancer who developed an acute myocardial infarction during 5-FU infusion. The patient was not affected by prior heart disease and did not show any classic risk factors for coronary heart disease. Coronary angiography examination revealed no evidence of coronary stenosis, supporting the hypothesis of a coronary artery spasm related to 5-FU infusion. Given the great number of cancer patients receiving 5-FU containing chemotherapeutic regimens, this rare but severe cardiac side-effect may be observed in both cardiologic and oncologic clinical practice. We suggest a tight clinical monitoring of all patients receiving 5-FU infusions, even in those without a prior history of heart disease.

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