• Hematol. Oncol. Clin. North Am. · Aug 2013

    Review

    Ibrutinib (PCI-32765) in chronic lymphocytic leukemia.

    • Nitin Jain and Susan O'Brien.
    • Department of Leukemia, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
    • Hematol. Oncol. Clin. North Am. 2013 Aug 1; 27 (4): 851-60, x.

    AbstractB-cell receptor (BCR) signaling is essential for chronic lymphocytic leukemia (CLL) cell survival. Many kinases in the BCR signaling pathway are being studied as potential therapeutic targets. Ibrutinib (PCI-32765) is a novel first-in-class selective inhibitor of Bruton tyrosine kinase. Preclinical evidence suggests that ibrutinib inhibits CLL cell survival and proliferation and affects CLL cell migration and homing. Early clinical data in patients with CLL and non-Hodgkin lymphoma is encouraging. It is likely that ibrutinib and other drugs targeting the BCR pathway will become an integral component of CLL therapy.Copyright © 2013 Elsevier Inc. All rights reserved.

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