• I Hosbach and M Zenz.
• Klinik für Anästhesiologie, Intensiv- und Schmerztherapie, Berufsgenossenschaftliche Kliniken Bergmannsheil Bochum, Universitätsklinikum. hosbach@anaesthesia.de
• Schmerz. 2003 Jan 1; 17 (1): 60-2.

IntroductionThe intrathecal application of opioids is promoted as a safe and cost-efficient method to treat chronic pain of nonmalignant origin. But the way of application could trigger the appearance of otherwise rare side-effects. One of those side-effects could be the alteration of androgen hormones. Can a long-time-application of intrathecal opioids result in gynecomastia?MethodsCase-report of a 49 year old with chronic back and limb pain. Research for publications.ResultsThe close link between the begin of intrathecal application of opioids and the onset of gynecomastia in this patient refers to a causal correlation. Historic publications and new findings from animal research are supporting our hypothesis.ConclusionsFurther research is needed to support the clinical suspicion of a correlation between intrathecal opioids and gynecomastia. In case of a opioid-produced gynecomastia tests of the oestrogen-testosterone-ratio should be performed. An early substitution of testosterone could prevent a full fledged gynecomastia.

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