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Anesthesia and analgesia · Jun 2007
Review Comparative StudySevoflurane: are there differences in products?
- Max T Baker.
- Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA. max-baker@uiowa.edu
- Anesth. Analg. 2007 Jun 1; 104 (6): 1447-51, table of contents.
AbstractSevoflurane is currently available in the United States from two manufacturers: Ultane (Abbott Laboratories, Inc.) and a generic product, Sevoflurane Inhalation Anesthetic (Baxter Healthcare Corp.). These products are rated therapeutically equivalent by the Food and Drug Administration, but there are some differences. Ultane is made in a single-step synthetic process and generic sevoflurane is manufactured using a three-step process. Ultane contains >300 ppm water and generic sevoflurane contains < or =130 ppm water. Ultane is supplied in a plastic polyethylene naphthalate polymer bottle, while generic sevoflurane is supplied in lacquer-lined aluminum bottles. The manufacturing processes and impurities, sevoflurane degradation resulting from Lewis acid reactions, and suitability of nonglass containers for sevoflurane are discussed.
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