Anesthesia and analgesia
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Anesthesia and analgesia · Jun 2007
Comparative StudyExperimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression.
Patients with chronic pain frequently suffer affective disorders, particularly anxiety and depression. Although clinical research on the relationship between pain and depressive symptoms has been done, it is not clear whether pain causes depression or depression exaggerates pain. To investigate the relation between pain and affect, we measured anxiety and depression-related behaviors in mice after spinal nerve ligation using classical behavioral tests. ⋯ Nerve injury can trigger affective disturbances in mice that appear much later than sensory hypersensitivity.
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Anesthesia and analgesia · Jun 2007
ReviewMagnesium as an adjuvant to postoperative analgesia: a systematic review of randomized trials.
Randomized trials have reached different conclusions as to whether magnesium is a useful adjuvant to postoperative analgesia. ⋯ These trials do not provide convincing evidence that perioperative magnesium may have favorable effects on postoperative pain intensity and analgesic requirements. Perioperative magnesium supplementation prevents postoperative hypomagnesemia and decreases the incidence of postoperative shivering. It may be worthwhile to further study the role of magnesium as a supplement to postoperative analgesia, since this relatively harmless molecule is inexpensive, and the biological basis for its potential antinociceptive effect is promising.
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Anesthesia and analgesia · Jun 2007
Randomized Controlled Trial Comparative StudyAn evaluation of a single dose of magnesium to supplement analgesia after ambulatory surgery: randomized controlled trial.
Previous studies have suggested that magnesium may be a useful adjuvant to postoperative analgesia. ⋯ In patients undergoing ambulatory ilioinguinal hernia repair or varicose vein operations under general anesthesia supplemented with other analgesic adjuvants, pretreatment with IV magnesium sulfate 4 g has no impact on postoperative pain and analgesic consumption.
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Anesthesia and analgesia · Jun 2007
Randomized Controlled Trial Comparative StudyMultimodal analgesia to prevent propofol-induced pain: pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone.
Propofol is well-known for its pain on injection. Premixture with lidocaine or pretreatment with remifentanil reduces injection pain. A multimodal approach might offer additional mitigation of propofol injection pain. ⋯ The combination of two different analgesic modalities, remifentanil and lidocaine completely abolishes moderate and severe pain associated with propofol injection, and significantly reduces the incidence of mild pain when compared with each drug used alone.
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Anesthesia and analgesia · Jun 2007
Review Comparative StudyDo surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety.
Gabapentin and pregabalin have antiallodynic and antihyperalgesic properties useful for treating neuropathic pain. These properties may also be beneficial in acute postoperative pain. In this study we evaluated randomized, controlled trials examining the analgesic efficacy, adverse effects, and clinical value of gabapentinoids in postoperative pain. ⋯ Gabapentinoids effectively reduce postoperative pain, opioid consumption, and opioid-related adverse effects after surgery. Conclusions about the optimal dose and duration of the treatment cannot be made because of the heterogeneity of the trials. Studies are needed to determine the long-term benefits, if any, of perioperative gabapentinoids.