• Indian J Pharmacol · Aug 2010

    Unusual nail pigmentation following cyclophosphamide-containing chemotherapy regimen.

    • Santosh Kumar, Rakesh Dixit, Saurabh Karmakar, and Sayan Paul.
    • Department of Pulmonary Medicine, Chhatrapati Shahuji Maharaj Medical University (erstwhile King George Medical University), Lucknow, Uttar Pradesh, India.
    • Indian J Pharmacol. 2010 Aug 1; 42 (4): 243-4.

    AbstractCyclophosphamide therapy may rarely cause pigmentation of the nails which is of different patterns. We report a patient who developed pigmentation of nails after six cycles of cyclophosphamide, methotrexate, and 5-flourouracil chemotherapy, each repeated after 28 days for breast cancer. The patient developed nail pigmentation that started proximally and spread distally and involved all the nails of both hands and feet except the second and third toenails of right foot. Using Naranjo ADR Probability Scale, the case revealed a "probable" association with cyclophosphamide.

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