• Nippon Rinsho · Feb 1996

    Review

    [Proliferation of alveolar epithelial cells and gene expression of surfactant proteins in adult respiratory distress syndrome (ARDS)].

    • K Sugahara.
    • Department of Anesthesiology, Kumamoto University School of Medicine.
    • Nippon Rinsho. 1996 Feb 1; 54 (2): 341-5.

    AbstractRegeneration of alveolar epithelial cells is one of the important repair processes in many types of lung injury, including the adult respiratory distress syndrome (ARDS). We have examined the effects of growth factors and cytokines on alveolar epithelial cells in vitro, and also examined histopathology and surfactant protein gene expressions in alveolar epithelial cells in rats with endotoxin-induced lung injury. Keratinocyte growth factor only induced a marked increase in levels of mRNAs for SP-A and SP-B, accompanied by an increase in SP-A protein. Intratracheal administration of endotoxin induced the marked proliferation of alveolar type II cells in association with the increased surfactant protein mRNAs, and SP-A production. Proliferation and differentiation of alveolar epithelial cells, and KGF may play important roles of repair process of the damaged alveoli after acute lung injury.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…