• R Jovic, D Dragicevic, Z Komazec, and A Sabo.
• Ear, Nose and Throat Clinic, University Teaching Hospital Novi Sad, Novi Sad, Serbia.
• J Buon. 2008 Oct 1; 13 (4): 519-23.

PurposeRecently, nonsteroidal analgoantipyretics are recommended in the management of postoperative pain, with great attention to their safety. We conducted a randomized, single blind study to compare the analgesic efficacy and safety of ketoprofen and dipyrone (metamizole) after major head and neck surgery.Patients And Methods60 patients received postoperatively 100 mg ketoprofen or 2.5 g metamizole i.v. every 8h over 72h with additional administration of tramadol in case of inadequate analgesia. Pain was assessed by visual numeric scale every 2h during the 72h.ResultsPatients in both groups had similar pain score during the first 2 postoperative days, while on the 3rd postoperative day patients in the ketoprofen group had significantly lower pain score (p <0.05).ConclusionThe efficacy of ketoprofen to achieve postoperative analgesia was comparable to metamizole during the first 48h, while ketoprofen was superior to metamizole during the 3rd postoperative day.

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