• Curr Opin Anaesthesiol · Oct 2011

    Review

    The pathophysiology of acute pain: animal models.

    • Jun Xu and Timothy J Brennan.
    • Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois, USA.
    • Curr Opin Anaesthesiol. 2011 Oct 1; 24 (5): 508-14.

    Purpose Of ReviewTrauma, surgery, and burns are three common clinical scenarios that are associated with significant acute pain. This review describes the pathophysiology of acute pain utilizing three preclinical models: surgery, burn, and fracture.Recent FindingsIn general, there is greater interest directed toward peripheral mediators of acute pain. Studies indicate that treatment against nerve growth factor, interleukins, and ischemic-like mediators may provide valuable avenues for treatment of acute pain. By targeting the periphery, analgesic therapies may have reduced side-effects.SummaryPeripheral mediators of acute pain can vary depending upon the type of injury. Treatment aimed toward those mediators specific to the injury may improve acute pain management in the future. It will be important to translate these findings into clinical trials in the future.

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