• J Clin Anesth · Nov 2016

    Dexmedetomidine acts as an oxidative damage prophylactic in rats exposed to ionizing radiation.

    • Dilek Kutanis, Engin Erturk, Ahmet Besir, Yucel Demirci, Selcuk Kayir, Ali Akdogan, Birgul Vanizor Kural, Zumrut Bahat, Emine Canyilmaz, and Hanife Kara.
    • Karadeniz Technical University, Medical Faculty, Department of Anaesthesiology and Intensive Care, Trabzon, Turkey. Electronic address: dilekkutanis@gmail.com.
    • J Clin Anesth. 2016 Nov 1; 34: 577-85.

    Study ObjectiveTo investigate the effects of dexmedetomidine on oxidative injury caused by ionizing radiation.DesignRandomized controlled experimental study.SettingDepartment of radiation oncology and research laboratory of an academic hospital.InterventionsTwenty-eight rats were randomized to 4 groups (n=7 per group). Group S rats were administered physiologic serum; group SR rats were administered physiologic serum and 10 Gy external ionizing radiation. Groups D100 and D200 were administered 100 and 200 μg/kg dexmedetomidine intraperitoneally, respectively, 45 minutes before ionizing radiation.MeasurementsLiver, kidney, lung, and thyroid tissue and serum levels of antioxidant enzymes (glutathione peroxidase [GPX], superoxide dismutase, and catalase) and oxidative metabolites (advanced oxidation protein products, malondialdehyde, and nitrate/nitrite, and serum ischemia-modified albumin) were measured 6 hours postprocedure.Main ResultsIn group SR, IR decreased antioxidant enzyme levels and increased oxidative metabolite levels (P<.05). In plasma, antioxidant enzyme levels were higher and oxidative metabolite levels were lower in groups D100 and D200 than in group SR (P<.01). In tissues, hepatic and lung GPX levels were higher in groups D100 and D200 than in group SR (P<.001). Renal and thyroid GPX levels were higher in D200 than in group SR (P<.01). Thyroid superoxide dismutase levels were higher in groups D100 and D200 than in group SR (P<.01). Renal, lung, and thyroid catalase levels were higher in group D200 than in group SR (P<.01). Hepatic, renal, and lung advanced oxidation protein products and malondialdehyde levels were lower in groups D100 and D200 than in group SR (P<.01). Hepatic, renal, and lung nitrate/nitrite levels were lower in group D200 than in group SR (P<.05).ConclusionsDexmedetomidine preserves the antioxidant enzyme levels and reduces toxic oxidant metabolites. Therefore, it can provide protection from oxidative injury caused by ionizing radiation.Copyright © 2016 Elsevier Inc. All rights reserved.

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