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- L A Lievense, K Bezemer, J G J V Aerts, and J P J J Hegmans.
- Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. l.lievense@erasmusmc.nl
- Lung Cancer. 2013 Jun 1; 80 (3): 256-62.
AbstractTumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest. In this review we will discuss the importance of TAMs in the pathogenesis and clinical outcome of lung cancer and mesothelioma patients. In addition, the potential of TAMs as therapeutic targets will be discussed.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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