• William J Sheehan, Elaine B Hoffman, Chunxia Fu, Sachin N Baxi, Ann Bailey, Eva-Maria King, Martin D Chapman, Jeffrey P Lane, Jonathan M Gaffin, Perdita Permaul, Diane R Gold, and Wanda Phipatanakul.
• Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA.
• Ann. Allergy Asthma Immunol. 2012 Jun 1; 108 (6): 418-22.

BackgroundEndotoxins are stimulators of the immune system and, despite their potential to protect against allergy, have been associated with early wheezing and asthma morbidity.ObjectiveTo compare inner-city school endotoxin exposure with home endotoxin exposure in children with asthma.MethodsStudents with asthma were recruited from 12 urban elementary schools. Settled and airborne dust samples, linked to enrolled students, were collected from school classrooms, gymnasiums, and cafeterias twice during the academic year. For comparison, settled dust was collected once from the bedrooms of students with asthma.ResultsTwo hundred twenty-nine school settled dust samples and 118 bedroom settled dust samples were collected and analyzed for endotoxin. The median endotoxin concentration for school samples was 13.4 EU/mg (range, 0.7-360.7 EU/mg) and for home samples was 7.0 EU/mg (range = LLOD-843.0 EU/mg). The median concentration within each individual school varied from 6.6 EU/mg to 24.0 EU/mg. One hundred four students with asthma had matched classroom and bedroom endotoxin exposure measurements performed in the same season and demonstrated significantly higher concentrations of endotoxin in the students' classrooms (mean log value, 1.13 vs 0.99, P = .04). The median of the classrooms was 12.5 EU/mg compared with their bedrooms, with a median of 7.0 EU/mg. Within the school environment, no significant difference was seen between the fall and spring samples (mean log value 1.14 vs 1.09; P = .35).ConclusionInner-city children with asthma were exposed to higher concentrations of endotoxin in their classrooms as compared with their bedrooms. Further studies are needed to evaluate school endotoxin exposure as a factor in asthma morbidity.Copyright © 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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