Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Jun 2012
Endotoxin exposure in inner-city schools and homes of children with asthma.
Endotoxins are stimulators of the immune system and, despite their potential to protect against allergy, have been associated with early wheezing and asthma morbidity. ⋯ Inner-city children with asthma were exposed to higher concentrations of endotoxin in their classrooms as compared with their bedrooms. Further studies are needed to evaluate school endotoxin exposure as a factor in asthma morbidity.
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Ann. Allergy Asthma Immunol. · Jun 2012
17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.
Although an association between 17q12-21 and asthma has been replicated across different populations, some inconsistencies have been found between different studies. ⋯ We found 1 novel association and replicated several previously reported associations between 17q12-21 polymorphisms and asthma. We demonstrated significant interactions between active smoking and polymorphisms in 17q12-21 with asthma, lung function, and AHR in adults. Our data confirm that 17q12-21 is an important asthma susceptibility locus.