• Matilde Zaballos, Emilia Bastida, Consolación Jiménez, Salomé Agustí, and M Teresa López-Gil.
• Department of Toxicology, Complutense University, Madrid, Spain. mati@plagaro.net
• Eur J Anaesthesiol. 2013 Apr 1;30(4):170-4.

ContextThe single-use Laryngeal Mask Airway (LMA) Supreme is a new supraglottic airway device. It has been reported to be reliable and easy-to-use in clinical practice; however, the anaesthetic techniques for its insertion are not standardised.ObjectivesThe purpose of this study was to determine the ED50 of end-tidal sevoflurane concentration for successful LMA Supreme insertion without the use of neuromuscular blockade.DesignA prospective observational study.SettingA single tertiary care surgical centre.PatientsThirty-one consecutive elective patients scheduled for minor elective surgery under general anaesthesia.InterventionPatients were preoxygenated with 100% oxygen and anaesthetised using normal tidal volume inhalation of sevoflurane. The target sevoflurane concentration was determined using a modified Dixon's 'up-and-down' method (starting at 2.5% with 0.5% as the step size). After the predetermined end-tidal concentration had been established and maintained for 10 min, LMA Supreme insertion was attempted.Main Outcome MeasureThe main outcome measure was the patient's response to LMA Supreme insertion, classified as either 'movement' or 'no movement'. The mean of the concentrations of seven cross-overs from 'movement' to 'no movement' was used to estimate the ED50.ResultsThe estimated sevoflurane concentration for successful LMA Supreme insertion in 50% of adults was 3.03 ± 0.75% (95% confidence interval 2.3 to 3.7%). The values of the ET50 and ET95 obtained by logistic regression were 2.83 and 5.30%, respectively.ConclusionSevoflurane alone can provide acceptable conditions for insertion of the LMA Supreme in adults, at an estimated minimum alveolar anaesthetic concentration of 3% with minimal adverse effects.

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