• Ahmad Amin, Arezoo Mohamadifar, Mohammad Sadegh Keshmiri, Behshid Ghadrdoost, Sepideh Taghavi, and Nasim Naderi.
• Department of Heart Failure and Transplantation, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Science, Tehran, Iran. Electronic address: amina33@gmail.com.
• J Crit Care. 2017 Apr 1; 38: 324-327.

BackgroundPredicting prognosis is a cornerstone in management of pulmonary arterial hypertension. Hemodynamic parameters are among the robust indicators of right ventricular function and prognosis. In this study we have investigated the association of a simple hemodynamic parameter with clinical worsening in pulmonary arterial hypertension.Methods And Patients120 patients were enrolled in a single center prospective cohort study after confirmation of precapillary pulmonary hypertension and were followed for an average of 36months on guideline recommended treatment protocols. cSvO2 was calculated as the ratio of right atrial pressure over Mixed Venous Oxygen Saturation. Independent predictors of clinical worsening were identified using multivariable Cox regression models.ResultsBy the end of the follow up a total of 21 patients died and 63 were hospitalized for pulmonary hypertension. Time-to-event Cox regression model showed a strong association between cSvO2 and time to clinical worsening (HR: 250.13, CI: (38.56-1622.34) &p-value: <0.0001).ConclusionThe index of cSvO2 includes both parameters of cardiac output and right ventricular filling pressure and might be beneficial in predicting clinical worsening in patients with pulmonary arterial hypertension.Copyright © 2016 Elsevier Inc. All rights reserved.

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