• Neuroscience · Mar 2017

    Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing ca1 pyramidal neurons.

    • Alberto Sánchez-Aguilera, José Luis Sánchez-Alonso, María Ángeles Vicente-Torres, and Asunción Colino.
    • Departamento de Fisiología, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain. Electronic address: alberto.sanchez_aguilera_lopez@kcl.ac.uk.
    • Neuroscience. 2017 Mar 6; 344: 89-101.

    AbstractThe firing pattern of individual neurons is an important element for information processing and storing. During the first weeks of development, there is a transitional period during which CA1 pyramidal neurons display burst-spiking behavior in contrast to the adult regular-firing pattern. Spike after-depolarizations (ADPs) constitute a major factor underlying burst-spiking behavior. Using current-clamp recordings, we studied ADP waveforms and firing patterns in CA1 pyramidal neurons of Wistar rats from 9 to 19 postnatal days (P9-19). The percentage of burst-spiking neurons increased up to P16, in correlation with the emergence of an active component in the ADP. The application of low-voltage-activated (LVA) calcium channel blockers such as nickel or mibefradil suppressed the generation of the active ADP component and burst-spiking behavior. In agreement with the development of the ADP waveform and burst-spiking behavior, voltage-clamp experiments in dissociated pyramidal neurons showed an increase in the LVA calcium current in P16-19 vs P9-12. Finally, we found that a reduction of extracellular calcium levels decreases the percentage of burst-spiking cells due to a reduction in the active component of the ADP. We conclude that a major contribution of LVA calcium channels to ADP determines the bursting capability of CA1 pyramidal neurons during a transitional postnatal period in contrast to adulthood.Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

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