• Chunhai Tang, Yun Bao, Min Qi, Lizhi Zhou, Fan Liu, Jian Mao, Qingmei Lei, Songtao Qi, and Binghui Qiu.
• Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China; Department of Neurosurgery, Tenth Affiliated Hospital, Guangxi Medical University, Guangdong Province, China.
• J Crit Care. 2017 Jun 1; 39: 267-270.

PurposeTo evaluate the efficacy and safety of mild induced hypothermia for intracranial hypertension in patients with traumatic brain injury after decompressive craniectomy.MethodsA total of 60 adults with intracranial pressure (ICP) of more than 20 mm Hg after decompressive craniectomy were randomly assigned to standard care (control group) or hypothermia (32°C-35°C) plus standard care. Then, ICP, cerebral perfusion pressure, Glasgow Outcome Scale score, and complications were assessed.ResultsThere was a significant difference in ICP and cerebral perfusion pressure between the 2 groups. Favorable outcomes occurred in 12 (40.0%) and 7 (36.5%) patients in the hypothermia and control groups, respectively (P=.267). Kaplan-Meier curves revealed a marked difference in survival between the hypothermia and control groups (P=.032). There were significant differences in pulmonary infection and electrolyte disorders between the hypothermia and control groups (P=.038 and .033, respectively).ConclusionMild induced hypothermia can reduce intracranial hypertension after decompressive craniectomy, decreasing patient mortality. Hypothermia should be considered one of the main treatments for intracranial hypertension after decompressive craniectomy in patients with traumatic brain injury.Copyright © 2016 Elsevier Inc. All rights reserved.

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