• Eun-Su Choi, Woo-Jin Jeong, Soon-Hyun Ahn, Ah-Young Oh, Young-Tae Jeon, and Sang-Hwan Do.
• Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.
• J Clin Anesth. 2017 Feb 1; 36: 102-106.

Study ObjectiveWe evaluated the effect of magnesium sulfate-an enhancer of neuromuscular blockade-on onset and duration of low dose of rocuronium, and on operating conditions during laryngeal microsurgery.DesignRandomized, prospective, double-blinded study.PatientsEighty-four patients scheduled for elective laryngeal microsurgery.InterventionsPatients were randomly allocated to receive different doses of rocuronium: 0.6 mg/kg (group C, n=28), 0.45 mg/kg (group LR, n=28), or 0.45 mg/kg plus magnesium sulfate 30 mg/kg (group LM, n=28).MeasurementsWe measured the onset time and duration of action of rocuronium, and evaluated the surgeon's satisfaction with the operating conditions.Main ResultsGroup LR showed significantly delayed onset time (group C: 87±22 seconds, group LR: 127±47 seconds, and group LM: 89±32 seconds; P=.001) and maximal suppression than did other groups (group C: 102±30 seconds, group LR: 155±66 seconds, and group LM: 105±36 seconds; P=.002). Duration of action of rocuronium was significantly longer in group C than in other groups (group C: 39±7 minutes, group LR: 28±8 minutes, group LRM: 31±8 minutes; P<.001). Laryngoscope placement score (P=.002), surgeon's satisfaction (P=.005), and sore throat (P=.035) were significantly worse in group LR.ConclusionsMagnesium sulfate 30 mg/kg accelerated the onset and improved operating conditions of low-dose rocuronium without prolongation of action.Copyright © 2016 Elsevier Inc. All rights reserved.

This article appears in the collection: Magnesium the new 'roid.

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