• Andrew J Hahne, Jon J Ford, Matthew C Richards, Luke D Surkitt, Chan Alexander Y P AYP, Sarah L Slater, and Nicholas F Taylor.
• *Low Back Research Team, School of Allied Health, La Trobe University, Melbourne, Australia †Physiotherapy Department, Northern Health, Melbourne, Australia.
• Spine. 2017 Nov 1; 42 (21): E1215-E1224.

Study DesignA preplanned effect modifier analysis of the Specific Treatment of Problems of the Spine randomized controlled trial.ObjectiveTo identify characteristics associated with larger or smaller treatment effects in people with low back disorders undergoing either individualized physical therapy or guideline-based advice.Summary Of Background DataIdentifying subgroups of people who attain a larger or smaller benefit from particular treatments has been identified as a high research priority for low back disorders.MethodsThe trial involved 300 participants with low back pain and/or referred leg pain (≥6 wk, ≤6 mo duration), who satisfied criteria to be classified into five subgroups (with 228 participants classified into three subgroups relating to disc-related disorders, and 64 classified into the zygapophyseal joint dysfunction subgroup). Participants were randomly allocated to receive either two sessions of guideline based advice (n = 144), or 10 sessions of individualized physical therapy targeting pathoanatomical, psychosocial, and neurophysiological factors (n = 156). Univariate and multivariate linear mixed models determined the interaction between treatment group and potential effect modifiers (defined a priori) for the primary outcomes of back pain, leg pain (0-10 Numeric Rating Scale) and activity limitation (Oswestry Disability Index) over a 52-week follow-up.ResultsParticipants with higher levels of back pain, higher Örebro scores (indicative of higher risk of persistent pain) or longer duration of symptoms derived the largest benefits from individualized physical therapy relative to advice. Poorer coping also predicted larger benefits from individualized physical therapy in the univariate analysis.ConclusionThese findings suggest that people with low back disorders could be preferentially targeted for individualized physical therapy rather than advice if they have higher back pain levels, longer duration of symptoms, or higher Örebro scores.Level Of Evidence2.

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