• Clin Lab · Jan 2013

    Plasma levels of CXCL1 (GRO-alpha) and CXCL10 (IP-10) are elevated in type 2 diabetic patients: evidence for the involvement of inflammation and angiogenesis/angiostasis in this disease state.

    • Seyyed Mohamad Ali Sajadi, Hossein Khoramdelazad, Gholamhossein Hassanshahi, Houshang Rafatpanah, Javad Hosseini, Mehdi Mahmoodi, Mohammad Kazemi Arababadi, Reza Derakhshan, Roshanak Hasheminasabzavareh, Seyed-Mostafa Hosseini-Zijoud, and Zahra Ahmadi.
    • Department of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
    • Clin Lab. 2013 Jan 1; 59 (1-2): 133-7.

    BackgroundRecent evidence has demonstrated that environment and genetic factors play pivotal roles in diabetes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-alpha) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls.MethodsPeripheral blood samples were collected from 100 type 2 diabetic patients and 150 healthy controls. Circulating CXCL1 and CXCL10 levels were measured by ELISA.ResultsElevated serum levels of both CXCL1 and CXCL10 were found in type 2 diabetic patients in comparison to controls.ConclusionsElevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes.

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