• Neuroscience · Jun 2017

    Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex.

    • Yingxue Huang, Guohong Li, Lei An, Yanle Fan, Xinran Cheng, Xuzhao Li, Yupeng Yin, Rihua Cong, Shulin Chen, and Shanting Zhao.
    • College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi 712100, PR China.
    • Neuroscience. 2017 Jun 3; 352: 39-51.

    AbstractFyn is a non-receptor protein tyrosine kinase that belongs to Src family kinases. Fyn plays a critical role in neuronal migration, but the mechanism remains unclear. Here, we reported that suppression of Fyn expression in mouse cerebral cortex led to migration defects of both early-born and late-born neurons. Morphological analysis showed that loss of Fyn function impaired multipolar-bipolar transition of newly generated neurons and neurite formation in the early phase of migration. Moreover, Fyn inhibition increased the length of leading process and decreased the branching number of the migrating cortical neurons. Together, these results indicate that Fyn controls neuronal migration by regulating the cytoskeletal dynamics and multipolar-bipolar transition of newly generated neurons during cortical development.Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

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