• Neuroimaging Clin. N. Am. · May 2017

    Review

    Cortical Gray Matter MR Imaging in Multiple Sclerosis.

    • Massimiliano Calabrese and Marco Castellaro.
    • Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro 10, Verona 37134, Italy. Electronic address: massimiliano.calabrese@univr.it.
    • Neuroimaging Clin. N. Am. 2017 May 1; 27 (2): 301-312.

    AbstractSeveral neuropathologic and imaging studies have consistently confirmed that multiple sclerosis affects both white (WM) and gray matter (GM) and that GM damage plays a key role in disability progression. However, differently from WM damage, the less inflammatory cell infiltration, the absence of significant blood-brain barrier damage, the low myelin density in upper cortical layers, as well as technical constraints, make the GM damage almost undetectable by means of conventional MR imaging.Copyright © 2016 Elsevier Inc. All rights reserved.

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