Several neuropathologic and imaging studies have consistently confirmed that multiple sclerosis affects both white (WM) and gray matter (GM) and that GM damage plays a key role in disability progression. However, differently from WM damage, the less inflammatory cell infiltration, the absence of significant blood-brain barrier damage, the low myelin density in upper cortical layers, as well as technical constraints, make the GM damage almost undetectable by means of conventional MR imaging.
Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro 10, Verona 37134, Italy. Electronic address: massimiliano.calabres... more e@univr.it. less
Neuroimaging Clin. N. Am. 2017 May 1; 27 (2): 301-312.