• Ann. Clin. Lab. Sci. · Jan 2002

    Comparative Study

    Ultrastructural comparison of "alveolar" and "solid" areas in bronchioloalveolar carcinoma.

    • Farbod Darvishian, Beth Roberts, Saul Teichberg, and Hajdu I Steven.
    • Department of Pathology, North Shore University Hospital, Manhasset, New York 11030, USA.
    • Ann. Clin. Lab. Sci. 2002 Jan 1; 32 (3): 225-30.

    AbstractThe purpose of this study was to compare the ultrastructural features of bronchioloalveolar carcinomas, contrasting the well-differentiated alveolar component and the poorly-differentiated solid component in the same tumor. We studied 7 cases of non-mucinous bronchioloalveolar carcinomas by electron microscopy. Two of these cases showed lamellar bodies in both the alveolar and solid components and the remaining 5 cases revealed Clara cell granules in both components. We conclude that the neoplastic cells in bronchioloalveolar carcinoma retain their ultrastructural phenotypes after becoming invasive carcinoma with loss of alveolar differentiation.

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