• Muhammed Keskin, Tolga Sinan Güvenç, Mert İlker Hayıroğlu, Adnan Kaya, Mustafa Adem Tatlısu, Şahin Avşar, Ahmet Öz, Taha Keskin, Ahmet Okan Uzun, and Ömer Kozan.
• Sultan Abdulhamid Han Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. Electronic address: drmuhammedkeskin@gmail.com.
• J Crit Care. 2017 Oct 1; 41: 183-190.

BackgroundThrombolysis in Myocardial Infarction (TIMI) risk index (TRI) was recently evaluated in patients with acute myocardial infarction and found as an important prognostic index. In the current study, we evaluated the prognostic value of TRI in patients with moderate-high and high risk pulmonary embolism (PE) who were treated with thrombolytic agents.MethodsWe retrospectively evaluated the in-hospital and long-term (4-year) prognostic impact of TRI in a total number of 456 patients with moderate-high and high risk PE. Patients were stratified by quartiles (Q) of admission TRI.ResultsIn-hospital analysis revealed significantly higher rates of in-hospital death for patients with TRI in Q4. After adjustment for confounding baseline variables, TRI in Q4 was associated with 2.8-fold hazard of in-hospital death. Upon multivariate analysis, admission TRI in Q4 vs. Q1-3 was associated with 3.1 fold hazard of 4-year mortality rate.ConclusionTRI in Q4, as compared to Q1-3, was significantly predictive of short term and long-term outcomes in PE patients who treated with thrombolytic agents. Our data suggest TRI to be an independent, feasible, and cost-effective tool for rapid risk stratification in moderate-high and high risk PE patients who treated with thrombolytic agents.Copyright © 2017 Elsevier Inc. All rights reserved.

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