• Ida F Ukor, Andrew K Hilton, Michael J Bailey, and Rinaldo Bellomo.
• Department of Intensive Care, Austin Hospital, Heidelberg 3081, Melbourne, VIC, Australia; Department of Anaesthesia and Perioperative Medicine, Monash Medical Centre, Clayton 3168, Melbourne, VIC, Australia. Electronic address: IdaFong.Ukor@monashhealth.org.
• J Crit Care. 2017 Oct 1; 41: 254-259.

PurposeThis pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers.Materials And MethodsSix healthy male volunteers aged 18-65years were randomized to receive 1L NS given over 30min or 120min. On a subsequent study session the alternate fluid regimen was administered. Haemodynamic data was gathered using a non-invasive finger arterial pressure monitor (Nexfin®), echocardiography and carotid duplex sonography. Time to micturition and urine volume was also assessed.ResultsCompared to baseline, rapid infusion of 1L of saline over 30min produced a fall in Nexfin®-measured CO by 0.62L/min (p<0.001), whereas there was a marginal but significant increase during infusion of 1L NS over 120min of 0.02L/min (p<0.001). This effect was mirrored by changes in HR and blood pressure (BP) (p<0.001). There were no significant changes in carotid blood flow, time to micturition, or urine volume produced.ConclusionsSlower infusion of 1L NS in healthy male volunteers produced a greater increase in CO, HR and BP than rapid infusion.Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

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