• Neuroscience · Feb 2018

    HLA-G∗14bp insertion and the KIR2DS1-HLAC2 complex impact on behavioral impairment in children with Autism Spectrum Disorders.

    • Franca R Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Alessandro Ghezzo, Salvatorica Manca, Michela Zanette, Stefano Sotgiu, MensiMaria MartinaMMChild Neurology and Psychiatry Unit, C. Mondino National Neurological Institute, Pavia, Italy., Milena Zanzottera, Cristina Agliardi, Andrea S Costa, Umberto Balottin, and Mario Clerici.
    • Don C. Gnocchi Foundation IRCCS, Milano, Italy. Electronic address: fguerini@dongnocchi.it.
    • Neuroscience. 2018 Feb 1; 370: 163169163-169.

    AbstractActivating KIR-HLA-C ligand complexes and HLA-G∗14bp insertion/deletion (+/-) polymorphism were associated to Autism Spectrum Disorders (ASD) and were suggested to correlate with inflammation during fetal development. We evaluated whether HLA-G∗14bp(+/-) and KIR-HLA-C complexes are associated with cognitive and behavioral scores and EEG profile in 119 ASD children (58 from Sardinia, 61 from Peninsular Italy). KIR2DS1-C2; KIR2DS2-C1; KIR2DL1-C2; KIR2DL2-C1; KIR2DL3-C1 and HLA-G∗14bp(+/-) were molecularly genotyped by Single Specific Primer PCR and gel electrophoresis. Univariate linear model analysis adjusted for age, gender and provenience showed statistically higher scores of Childhood Autism Rating Scale (CARS) and Autistic Core Behavior in KIR2DS1-C2+/HLA-G∗14bp+ASD children (43.7±1.5, p=0.03; 3.3±0.1, p=0.03, respectively). These results suggested a synergistic polygenic association of KIR2DS1-HLAC2+/HLA-G∗14bp+ pattern with behavioral impairment in ASD children.Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

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