• Yong S Shim, Young Chul Youn, Duk L Na, Seong Yoon Kim, Hae-Kwan Cheong, So Young Moon, Kyung Won Park, Bon D Ku, Jun-Young Lee, Jee H Jeong, Heeyoung Kang, Eun-Joo Kim, Jung-Sun Lee, Seok Min Go, Sook Hui Kim, Kyung R Cha, and Sang Won Seo.
• Department of Neurology, Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Korea.
• Eur. Neurol. 2011 Jan 1; 66 (2): 75-82.

AimsWe conducted this study to investigate the independent association of medial temporal atrophy (MTA) and white matter hyperintensities (WMH) with cognitive impairments of Alzheimer's disease (AD) patients and the interaction between MTA and WMH.MethodsFrom 13 centers, a total of 216 AD patients were consecutively recruited and their MTA and WMH were visually rated. We evaluated the association of MTA and WMH with the various cognitive domains, and the interaction between MTA and WMH.ResultsMTA independently correlated with scores of the Mini-Mental State Examination (MMSE), Clinical Dementia Rating scale (CDR), delayed recalls of the Seoul Verbal Learning Test (SVLT), the Boston Naming Test (BNT), and Word Fluency. WMH independently correlated with MMSE, CDR, Digit Span, and Stroop word reading, but not with delayed recall. There were interactions of WMH and MTA on CDR (p = 0.004), SVLT (p = 0.023), BNT (p = 0.002) and the semantic Word Fluency (p = 0.007).ConclusionMTA and WMH independently affected cognitive deficits in AD patients, with somewhat different patterns where MTA was associated mostly with memory and language, while WMH were associated with attention and frontal executive functions. This study also showed interactions between MTA and WMH on some cognitive deficits and dementia severity, suggesting that they synergistically contribute to cognitive impairment in AD.Copyright © 2011 S. Karger AG, Basel.

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