• Am. J. Respir. Crit. Care Med. · Dec 2017

    Nocturnal Oximetry-based Evaluation of Habitually Snoring Children.

    • Roberto Hornero, Leila Kheirandish-Gozal, Gonzalo C Gutiérrez-Tobal, Mona F Philby, María Luz Alonso-Álvarez, Daniel Álvarez, Ehab A Dayyat, Zhifei Xu, Yu-Shu Huang, Maximiliano Tamae Kakazu, Albert M Li, Annelies Van Eyck, Pablo E Brockmann, Zarmina Ehsan, Narong Simakajornboon, Athanasios G Kaditis, Fernando Vaquerizo-Villar, Andrea Crespo Sedano, Sans Capdevila Oscar O 15 Sleep Unit, Department of Neurology, Sant Joan de Deu, Barcelona Children's Hospital, Barcelona, Spain., Magnus von Lukowicz, Joaquín Terán-Santos, Félix Del Campo, Christian F Poets, Rosario Ferreira, Katalina Bertran, Yamei Zhang, John Schuen, Stijn Verhulst, and David Gozal.
    • 1 Biomedical Engineering Group, University of Valladolid, Valladolid, Spain.
    • Am. J. Respir. Crit. Care Med. 2017 Dec 15; 196 (12): 1591-1598.

    RationaleThe vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and globally available, could potentially provide a reliable and convenient diagnostic approach for pediatric OSA.MethodsDeidentified nSpO2 recordings from a total of 4,191 children originating from 13 pediatric sleep laboratories around the world were prospectively evaluated after developing and validating an automated neural network algorithm using an initial set of single-channel nSpO2 recordings from 589 patients referred for suspected OSA.Measurements And Main ResultsThe automatically estimated apnea-hypopnea index (AHI) showed high agreement with AHI from conventional polysomnography (intraclass correlation coefficient, 0.785) when tested in 3,602 additional subjects. Further assessment on the widely used AHI cutoff points of 1, 5, and 10 events/h revealed an incremental diagnostic ability (75.2, 81.7, and 90.2% accuracy; 0.788, 0.854, and 0.913 area under the receiver operating characteristic curve, respectively).ConclusionsNeural network-based automated analyses of nSpO2 recordings provide accurate identification of OSA severity among habitually snoring children with a high pretest probability of OSA. Thus, nocturnal oximetry may enable a simple and effective diagnostic alternative to nocturnal polysomnography, leading to more timely interventions and potentially improved outcomes.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…