• Haixia Long, Bing Liu, Chao Wang, Xiaolong Zhang, Jin Li, Chunshui Yu, and Tianzi Jiang.
• College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou 310023, China; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
• Neuroscience. 2017 Oct 24; 362: 239-247.

AbstractPrevious studies have shown a close relationship between the serotonin system and working memory (WM), but the neural mechanism for the role of the serotonin system on the WM is unclear. The frontoparietal network is involved in WM and is associated with the serotonin system. Therefore, this study investigated the interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the frontoparietal network obtained from the independent component analysis in a large, young Chinese sample population. The current study found a significant interaction effect of 5-HTTLPR and rs6295 on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Moreover, the mean connectivity in the right inferior parietal lobule was positively correlated with WM performance. These brain network analysis findings could provide a new perspective on the neural mechanisms of gene-gene interactions and on individual differences in cognitive functions.Copyright © 2017. Published by Elsevier Ltd.

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