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Klinische Pädiatrie · Nov 2008
Case ReportsHodgkin lymphoma as second malignancy during continuing chemotherapy for childhood acute lymphoblastic leukemia.
- M Alebouyeh, F Moussavi, H Haddad-Deylami, and P Vossough.
- Department of Pediatric Hematology and Oncology, Shohada Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran-Tajrish, Iran. alebouyehm@yahoo.com
- Klin Padiatr. 2008 Nov 1; 220 (6): 388-90.
AbstractAcute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy in most parts of the world with a 5-year survival rate above 70%. Long-term survivors are at risk for treatment-related late effects and second malignant neoplasms (SMNs). SMNs occur with a mean latency of 6-6.7 years after ALL diagnosis but are rarely observed during maintenance chemotherapy (CT). Hodgkin lymphoma (HL) as a complication of ALL is very rare. We report two children with ALL who developed HL while receiving maintenance CT. Both received appropriate chemo- and radiotherapy (CT/RT) and have survived for more than10 years.
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