• David Bar-Or, Matthew Carrick, Allen Tanner, Mark J Lieser, Leonard T Rael, and Edward Brody.
• Trauma Research Dept, Swedish Medical Center, Englewood, CO 80113, USA; Trauma Research Dept, Medical Center of Plano, Plano, TX 75075, USA; Trauma Research Dept, St. Anthony Hospital, Lakewood, CO 80228, USA; Trauma Research Dept, Penrose Hospital, Colorado Springs, CO 80907, USA. Electronic address: dbaror@ampiopharma.com.
• J Crit Care. 2018 Feb 1; 43: 197-201.

AbstractSepsis is a leading cause of mortality in the U.S. and Europe. Sepsis and septic shock are the results of severe metabolic abnormalities following infection. Aerobic glycolysis (the Warburg Effect) is as much a hallmark of sepsis as it is of cancer. Warburg observed that cancer cells generated energy through glycolysis (generation of ATP through degradation of glucose, usually associated with anaerobic conditions) rather than through oxidative phosphorylation (generation of ATP through the mitochondrial inner membrane via the tricarboxylic acid cycle, usually associated with aerobic conditions). Although the initial pathways of cancer and sepsis may be different, the mechanisms which allow aerobic glycolysis to occur, even in the presence of oxygen, are similar. This review provides some evidence that reversing these steps reverses the Warburg Effect in model systems and some pathological consequences of this effect. Therefore, this implies that these steps might be modifiable in sepsis to reverse the Warburg Effect and possibly lead to better outcomes.Copyright © 2017 Elsevier Inc. All rights reserved.

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