• Journal of anesthesia · Dec 1997

    Effects of hemoglobin concentration and temperature on the in vitro release of cyanide from sodium nitroprusside.

    • Shigemasa Ikeda, Patricia A Frank, John F Schweiss, and Sharon M Homan.
    • Department of Anesthesiology, St. Louis University School of Medicine, St. Louis University, 3635 Vista Ave. at Grand Blvd., P.O. Box 15250, 63110-0250, St. Louis, MO, USA.
    • J Anesth. 1997 Dec 1; 11 (4): 277-279.

    PurposeThis in vitro study was performed to determine whether changes in hemoglobin (Hb) concentration and temperature influenced the amount of cyanide (CN-) released from sodium nitroprusside (SNP).MethodsCanine whole blood with a Hb concentration of 8.5 to 18.9 g·dl (5.3 to 18.9 mM) was equilibrated with SNP at either 37°C or 25°C, and CN- levels in plasma and red blood cells (RBC) were measured using the microdiffusion method.ResultsChanges in Hb concentration and temperature did not have any statistically significant effect on the CN- released from SNP in plasma. On the other hand, CN- levels in RBC decreased with increasing Hb concentrations. CN- levels in RBC were significantly lower at 25°C than at 37°C.ConclusionThough the Hb concentration and temperature changed the amount of CN- released from SNP in RBC, the change observed was not clinically significant.

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