• Taro Mizutani and Makoto Tanaka.
• Department of Critical Care Medicine Institute of Clinical Medicine, University of Tsukuba, 305, Tsukuba, Ibaraki, Japan.
• J Anesth. 1997 Dec 1; 11 (4): 280-287.

PurposeTo test the hypothesis that inhalation of aerosol of glyceryl trinitrate or sodium nitroprusside might produce selective pulmonary vasodilation, causing an improvement of oxygenation with minimal systemic hypotension as inhaled nitric oxide gas, we investigated the effect of inhaled nitroglycerine and sodium nitroprusside aerosol on hemodynamics and oxygenation in dogs with pulmonary hypertension.MethodsPulmonary hypertension was induced by a continuous infusion of 1.0 to 4.0μg·kg-1·min-1 U-46619 in anesthetized and mechanically ventilated dogs. Aerosol preparations consisted of normal saline, 250, 500, 1000, and 2000 ppm solutions of either glyceryl trinitrate or sodium nitroprusside were administered sequentially via the breathing circuit.ResultsInhaled nitroglycerine and sodium nitroprusside aerosol caused neither selective pulmonary vasodilation nor improved oxygenation in this pulmonary hypertension model, unlike inhaled nitric oxide gas.ConclusionThese findings suggest that inhaled nitroglycerine and sodium nitroprusside aerosol is not effective in improving hemodynamic derangement or oxygenation in pulmonary hypertension. However, the effect of the substances in higher dose ranges remains to be defined.

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