• Marco Ciapetti, Paola Mancinelli, Andrea Cecchi, Emma Borrelli, Velio Bocci, and Adriano Peris.
• Careggi Teaching Hospital, Intensive Care Unit for Trauma and Extracorporeal Supports, Florence, Italy. Electronic address: marcociapetti.mc@gmail.com.
• J Crit Care. 2018 Feb 1; 43: 220-224.

PurposeIn critically ill patient it is observed a severe oxidative stress, not only due to the acute pathology but also for some therapeutic treatments. The aim of the present study was to analyze the variations of non-enzymatic antioxidants in plasma during veno-venous ECMO-treatment in a homogeneous population of critical patients with ARDS.Materials And MethodsWe carried out a retrospective study enrolling all patients with ARDS by influence A H1N1 treated with veno-venous ECMO. In all patients included, we have recorded clinical and laboratory parameters considered indicators of oxidative stress during the first week of treatment.ResultsWith regard to non-enzymatic antioxidants evaluated, we observed that both albumin and uric acid decreased significantly, at all observation times, after ECMO-treatment [(25.88±4.51, 18.05±4.27, 16.32±4.57, 19.07±5.10, p<0.05)(g/l), (5.46±1.43, 2.30±1.15, 2.90±2.09, 2.07±1.03, p<0.05)(mg/dl), respectively]. At the same time the amount of insulin administered daily was increased with statistical significance (p=0.03).ConclusionsThe veno-venous ECMO-treatment causes a significant reduction of some of the major non-enzymatic antioxidants and a possible increase in insulin resistance in patients with ARDS by influence A H1N1.Copyright © 2017 Elsevier Inc. All rights reserved.

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