• Luisa Fofi, Valerio Orlandi, Nicola Vanacore, Maria C Mizzoni, Alba Rosa, Cinzia Aurilia, Gabriella Egeo, Pietro Casella, and Piero Barbanti.
• Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Italy.
• Cephalalgia. 2014 Aug 1; 34 (9): 671-678.

BackgroundHeadache is one of the most common symptoms after cocaine use.MethodsWe investigated headache frequency and characteristics and the correlation between headache and acute cocaine intake in a cross-sectional study in a consecutive series of chronic cocaine users.ResultsParticipation rate was 94.1%. Of the 80 subjects enrolled, 72 (90%) reported current headaches, in most cases migraine or probable migraine without aura. Of these 72, 29 (40.3%) had a headache history, whereas 43 (59.7%) reported de novo headache after beginning to use cocaine. After acute cocaine use, a large percentage of users reported headache attacks: 86.2% of previous headache sufferers (migraine or probable migraine without aura in all cases) and 93% of de novo headache sufferers (migraine/probable migraine without aura = 35; episodic tension-type headache = three patients; cocaine-induced headache= two patients). Most subjects reported that when they used cocaine headaches worsened.ConclusionChronic cocaine use frequently seems to worsen or induce headache with migraine or migraine-like characteristics, probably owing to a serotoninergic and dopaminergic system impairment. In headache sufferers, especially those with migraine headaches, clinicians should enquire into possible cocaine use.© International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

6 keywords...

hide…