• Zhifeng Zhang, Haihua Xu, Yunhui Zhang, Wei Li, Yanjie Yang, Tian Han, Zhihui Wei, Xue Xu, and Jingui Gao.
• Department of Pain Treatment, the Second Hospital of Tianjin Medical University, Tianjin 300211, China.
• J Clin Anesth. 2017 Dec 1; 43: 84-89.

Study ObjectiveNonsteroidal anti-inflammatory drugs (NSAIDs) play a role in pain relief, especially in postoperative pain caused by inflammation. They have demonstrated significant opioid dose-sparing effects, which help in reducing postoperative effects and opioid side effects. The objective of this meta-analysis was to explore the role of NSAIDs in reducing postoperative pain at different time intervals and provide reference for medication after lumbar spine surgery by a meta-analysis of randomized controlled trials (RCT).DesignA meta-analysis study of randomized controlled trials.SettingPostoperative recovery area.PatientsAdult patients who have undergone lumbar spine surgery.InterventionPatients received NSAIDs for pain control after lumbar spine surgery.MeasurementsStandardized mean difference (SMD) and 95%CI were used to evaluate the visual analog scale of postoperative pain.Main ResultsFour hundred and eight participants from eight studies were included in this study. The difference between the NSAIDs group and placebo is significant in 0-6, 12, and 24h groups (overall: SMD=-0.72, 95%CI -0.98 to -0.45; 0-6h: SMD=0.50, 95%CI -0.81 to -0.19; 12h: SMD=-1.07, 95%CI -1.45 to -0.70; 24h: SMD=-1.16, 95%CI -1.87 to -0.45). Heterogeneity and publication bias were observed in the 0-6 and 24h groups.ConclusionNSAIDs are effective in postoperative analgesia after lumbar spine surgery. The study type, NSAID dose, different surgery types, and analgesic type might influence the efficacy of NSAIDs.Copyright © 2017 Elsevier Inc. All rights reserved.

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