• Adrian Regli, Bart Leon De Keulenaer, Annamaria Palermo, and Peter Vernon van Heerden.
• Intensive Care Unit, Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia; Intensive Care Unit, Fiona Stanley Hospital, 102-118 Murdoch Drive, Murdoch, WA 6150, Australia; School of Medicine and Pharmacology, The University of Western Australia, Sterling Highway, Crawley, (Perth) WA 6009, Australia; Medical School, The Notre Dame University, Henry Road, Fremantle, WA 6160, Australia. Electronic address: adrian.regli@gmail.com.
• J Crit Care. 2018 Feb 1; 43: 390-394.

PurposeIntra-abdominal hypertension (IAH) is associated with impaired respiratory function. Animal data suggest that positive end-expiratory pressure (PEEP) levels adjusted to intra-abdominal pressure (IAP) levels may counteract IAH-induced respiratory dysfunction. In this pilot study, our aim was to assess whether PEEP adjusted for IAP can be applied safely in patients with IAH.Materials And MethodsWe included patients on mechanical ventilation and with IAH. Patients were excluded with severe cardiovascular dysfunction or severe hypoxemia or if the patient was in imminent danger of dying. Following a recruitment manoeuvre, the following PEEP levels were randomly applied: PEEP of 5cmH2O (baseline), PEEP=50% of IAP, and PEEP=100% of IAP. After a 30min equilibration period we measured arterial blood gases and cardio-respiratory parameters.ResultsFifteen patients were enrolled. Six (41%) patients did not tolerate PEEP=100% IAP due to hypoxemia, hypotension or endotracheal cuff leak. PaO2/FiO2 ratios were 234 (68), 271 (99), and 329 (107) respectively. The differences were significant (p=0.009) only between baseline and PEEP=100% IAP.ConclusionsPEEP=100% of IAP was not well-tolerated and only marginally improved oxygenation in ventilated patients with IAH.Copyright © 2017 Elsevier Inc. All rights reserved.

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