• Rustu Kose, Ozgur Sogut, Tuncer Demir, and Ibrahim Koruk.
• Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Rize University, Rize, Turkey. drosogut@harran.edu.tr
• Dermatol Surg. 2012 May 1; 38 (5): 760-6.

ObjectiveTo assess the in vivo hemostatic effect of a folkloric medicinal plant extract.Subjects And MethodsWistar rats were randomized into four groups of seven. Group 1, a control group, received no pretreatment and was irrigated with saline. Group 2 received no pretreatment and was irrigated with the plant extract. Group 3, a control group, received pretreatment with heparin and was irrigated with saline. Group 4 received pretreatment with heparin and was irrigated with the plant extract. A standardized skin-bleeding model was created using full-thickness skin defects on the Wistar rats' dorsal skin. To control bleeding, compressive dressings were placed after inserting 1 mL of the plant extract or saline into the bleeding area. Hemostasis time and amount of nasal bleeding were measured in all groups to compare the treatments without and with the plant extract.ResultsWithout heparin pretreatment, the folkloric medicinal plant extract shortened the hemostasis time by 1.29 minute and reduced the amount of bleeding by 0.63 g. With heparin pretreatment, the plant extract shortened the hemostasis time by 2.29 minutes and reduced the amount of bleeding by 0.70 g.ConclusionThe medicinal plant extract irrigation was more effective than saline irrigation for treating hemorrhagic skin defects in animals using a compressive dressing with or without heparin pretreatment.© 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

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