• Journal of critical care · Apr 2018

    Noninvasive ventilation failure in pneumonia patients ≥65years old: The role of cough strength.

    • Yueling Hong, Jun Duan, Linfu Bai, Xiaoli Han, Shicong Huang, and Shuliang Guo.
    • Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
    • J Crit Care. 2018 Apr 1; 44: 149-153.

    PurposeTo explore the association between cough strength and outcomes in elderly patients who received noninvasive ventilation (NIV) due to acute respiratory failure caused by pneumonia.Materials And MethodsWe enrolled patients ≥65years old with acute respiratory failure caused by pneumonia. Just before NIV treatment, cough strength was assessed on a cough-strength scale graded from 0 to 5. Patients graded 0-2 were defined as having no/weak coughs and those graded 3-5 were defined as having moderate/strong coughs.ResultsWe enrolled 349 patients in this study. The prevalence of no/weak cough was 24% (84/349). Moderate/strong cough patients had lower NIV failure (92/265 [34.7%] vs. 67/84 [79.8%], p<0.01) and lower hospital mortality (85/265 [32.1%] vs. 60/84 [71.4%], p<0.01) than no/weak cough patients. In multivariate logistic regression analysis, we also found that no/weak cough was an independent risk factor for NIV failure (odds ratio=13.83, 95% confidence interval: 6.01-31.81) and death in hospital (odds ratio=4.41, 95% confidence interval: 2.49-7.81).ConclusionsIn pneumonia patients ≥65years old, no/weak cough is associated with NIV failure and death in hospital. NIV must be used only with caution in no/weak cough patients.Copyright © 2017 Elsevier Inc. All rights reserved.

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