• Zhiyong Peng, Kaijiang Yu, Marlies Ostermann, XiuMing Xi, Raymond Hsu, Jean-Louis Vincent, John R Prowle, Bin Du, Martin Gallagher, Changsong Wang, Raghavan Murugan, Haibo Qiu, Thomas Rimmelé, Jianguo Li, Lui G Forni, Kianoush Kashani, Claudio Ronco, John A Kellum, and Acute Disease Quality Initiative (ADQI) Workgroup 19.
• Critical Care Medicine, Wuhan University Zhongnan Hospital, Wuhan 430071, Hubei, China. Electronic address: zn001590@whu.edu.cn.
• J Crit Care. 2018 Apr 1; 44: 337-344.

PurposeAcute kidney injury (AKI) has become a major medical and financial burden in China along with the rest of the world. There have been considerable advances in the understanding of the epidemiology and pathogenesis of AKI. However, there is no consensus regarding the optimal care for patients. The Acute Disease Quality Initiative (ADQI) 19 meeting focused on identifying and designing relevant and achievable AKI-related studies in China.Materials & MethodsThe working group developed a list of preliminary questions and objectives and performed analysis of the existing literature. Relevant studies were identified through a literature search using the MEDLINE database and bibliographies of relevant research and review articles. We then used a two-step Delphi process to prioritize a research agenda and proposed specific study designs to address unmet needs.ResultsImportant gaps in existing knowledge were identified and pragmatic studies were proposed in three distinct areas: care bundles for AKI prevention, renal replacement therapy (RRT) for AKI, and fluid management. In addition, the use of biomarkers to guide clinical trials was discussed.ConclusionsConsensus was reached on a research agenda for AKI with a specific focus on pragmatic trials in China.Copyright © 2017 Elsevier Inc. All rights reserved.

12 keywords...

hide…