• Methods Mol. Biol. · Jan 2010

    Isolation, culture and analysis of mouse mammary epithelial cells.

    • Matthew J Smalley.
    • Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
    • Methods Mol. Biol. 2010 Jan 1; 633: 139-70.

    AbstractLimited understanding of the cell biology of the breast and breast cancer hampers our ability to develop new therapeutic approaches. Mouse models of mammary gland development and tumourigenesis are key to developing new insights into the biology of both the normal and diseased tissues. Recent advances have enabled the isolation, molecular characterisation and functional analysis of mouse mammary epithelial cell subpopulations from the normal gland, including subpopulations enriched for stem cell behaviour. Application of these techniques both to the normal mammary gland and to tumour models will promote a better understanding of the nature of the different epithelial cell types in the mammary gland, the origins of mammary tumours and the role of tumour stem cells.

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